MOTS-c – 10mg

MOTS-c is a mitochondrial-derived peptide (MDP) consisting of 16 amino acids. Unlike most peptides encoded by nuclear DNA, MOTS-c is encoded within mitochondrial DNA, specifically in the 12S rRNA region. This unique origin highlights its role in metabolic regulation and cellular communication.

In scientific research, MOTS-c has been examined for its effects on energy homeostasis, glucose metabolism, stress adaptation, and exercise physiology. The peptide is supplied here in a 10mg lyophilized vial, ensuring stability and flexibility for laboratory investigations.

Composition and Structure

• Compound: MOTS-c peptide

• Sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

• Concentration: 10mg per vial

• Form: Lyophilized powder for reconstitution

• Molecular Weight: ~1,951 Da

The peptide’s biologically active form has been shown in preclinical models to activate AMP-activated protein kinase (AMPK), a master regulator of energy balance.

Biological Relevance

Metabolic Regulation

MOTS-c has been studied as a regulator of metabolic flexibility. By activating AMPK, it supports glucose uptake and energy utilization, processes that are central to metabolic balance.

Insulin Sensitivity and Glucose Control

Experimental evidence suggests that MOTS-c enhances insulin sensitivity in skeletal muscle, contributing to improved glucose control in metabolic research models.

Mitochondrial Function

As a mitochondrial-derived peptide, MOTS-c plays a unique role in cross-talk between mitochondria and the rest of the cell, influencing pathways involved in resilience and stress adaptation.

Exercise and Performance Research

MOTS-c has been linked in preclinical studies to endurance and physical performance, likely through enhanced energy efficiency and mitochondrial support.

Longevity and Stress Response

Research has identified MOTS-c as a candidate for aging-related studies, particularly in relation to oxidative stress, mitochondrial decline, and lifespan-associated pathways.

Research Applications

• Glucose Metabolism Studies: Evaluating effects on insulin sensitivity and energy utilization.

• Exercise Physiology: Assessing impacts on endurance, energy expenditure, and muscular performance.

• Mitochondrial Signaling Research: Investigating how mitochondrial peptides influence systemic biology.

• Aging Biology: Studying the peptide’s role in longevity-related pathways and stress resilience.

• Adaptive Stress Response Models: Exploring cellular adjustments to metabolic and oxidative stress.

Quality and Purity

• Produced under controlled laboratory conditions.

• Verified by analytical testing methods, including HPLC and mass spectrometry.

• Supplied in sterile, lyophilized powder form to ensure long-term stability.

• Each vial contains 10mg of MOTS-c for consistent research use.

Storage and Handling

• Unreconstituted (Lyophilized): Store at -20°C or below.

• Reconstituted: Store between 2–8°C and protect from light exposure.

• Avoid repeated freeze-thaw cycles to preserve peptide integrity.

Key Features

• High-purity MOTS-c peptide in a 10mg multi-use vial.

• Lyophilized powder format for stability and ease of storage.

• Suitable for research in metabolism, mitochondrial biology, and longevity.

• Rigorously tested for identity and purity.

Frequently Asked Questions

What is unique about MOTS-c compared to other peptides?
MOTS-c is encoded by mitochondrial DNA, giving it a distinct role in energy regulation and cellular signaling that sets it apart from nuclear-encoded peptides.

What are the main research areas associated with MOTS-c?
MOTS-c has been studied in relation to insulin sensitivity, glucose metabolism, mitochondrial function, exercise physiology, and aging biology.

What format is MOTS-c supplied in?
MOTS-c is provided in sterile, lyophilized powder form within a 10mg vial, designed for reconstitution prior to research use.

Can MOTS-c be used for human supplementation or medical treatment?
No. This product is strictly for laboratory research purposes. It is not intended for human consumption, medical use, or veterinary application.

MOTS-c (10mg) is supplied exclusively for research and laboratory purposes. It is not approved for human consumption, medical use, or veterinary application. Researchers are responsible for ensuring appropriate use in accordance with all applicable regulations.